Endocrine Abstracts

Excess adiposity, especially in visceral depots, is a major driver of insulin resistance, fatty liver and hyperglycaemia in type 2 diabetes mellitus (T2DM). Treatment guidelines for T2DM emphasise lifestyle measures (principally diet and exercise) with pharmacotherapy as additionally required to achieve glycaemic control. Therapeutic strategies ideally assist weight control, avoid hypoglycaemia and address cardiovascular, renal and other risks. Metformin (weight neutral), whic...

The incretin concept refers to components of the entero-insular axis that enhance the insulin response to a meal. The incretin effect is mostly attributed to the gut hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). The incretin effect is reduced in type 2 diabetes, and this appears to be due largely to reduced secretion of GLP-1. GLP-1 increases glucose-stimulated insulin secretion by pancreatic β-cells, reduces glucagon sec...

Aims/objectives: Glycerol cycling plays an essential regulatory role in metabolism in both health and disease. Aquaporins (AQPs) are a recently described family of water transporting membrane proteins, which contain a subset of members that also have the ability to transport glycerol across the cell membrane. This study sought to investigate the adipose tissue expression profile of AQPs in humans, and to assess the role of AQPs in adipocyte differentiation.<p class="abstex...